Publication

2017

  1. Soh SX, Siddiqui FJ, Allen JC, Kim GW, Lee JC, Yatabe Y, Soda M, Mano H, Soo RA, Chin TM, Ebi H, Yano S, Matsuo K, Niu X, Lu S, Isobe K, Lee JH, Yang JC, Zhao M, Zhou C, Lee JK, Lee SH, Lee JY, Ahn MJ, Tan TJ, Tan DS, Tan EH, Ong ST, Lim WT.“A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer” Oncotarget 2017. [PubMed]
  2. Nakamura T, Yamashita S, Fukumura K, Nakabayashi J, Tanaka K, Tamura K, Tateishi K, Kinoshita M, Fukushima S, Takami H, Fukuoka K, Yamazaki K, Matsushita Y, Ohno M, Miyakita Y, Shibui S, Kubo A, Shuto T, Kocialkowski S, Yamanaka S, Mukasa A, Sasayama T, Mishima K, Maehara T, Kawahara N, Nagane M, Narita Y, Mano H, Ushijima T & Ichimura K.“Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma” Acta Neuropathol 133, 321-4, 2017. [PubMed]

2016

  1. Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T & Mano H. “Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults” Nat Genet 48, 569-574, 2016. [PubMed]
  2. Ando M, Kawazu M, Ueno T, Koinuma D, Ando K, Koya J, Kataoka K, Yasuda T, Yamaguchi H, Fukumura K, Yamato A, Soda M, Sai E, Yamashita Y, Asakage T, Miyazaki Y, Kurokawa M, Miyazono K, Nimer SD, Yamasoba T & Mano H. “Mutational landscape and antiproliferative functions of ELF transcription factors in human cancer” Cancer Res 76, 1814-1824, 2016. [PubMed]
  3. Fukumura K, Kawazu M, Kojima S, Ueno T, Sai E, Soda M, Ueda H, Yasuda T, Yamaguchi H, Lee J, Shishido-Hara Y, Sasaki A, Shirahata M, Mishima K, Ichimura K, Mukasa A, Narita Y, Saito N, Aburatani H, Nishikawa R, Nagane M & Mano H. “Genomic characterization of primary central nervous system lymphoma” Acta Neuropathol 131, 865-875, 2016. [PubMed]
  4. Katsura A, Suzuki HI, Ueno T, Mihira H, Yamazaki T, Yasuda T, Watabe T, Mano H, Yamada Y & Miyazono K. “MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-beta” Genes Cells 21, 99-116, 2016. [PubMed]

2015

  1. Yamaguchi H, Kawazu M, Yasuda T, Soda M, Ueno T, Kojima S, Yashiro M, Yoshino I, Ishikawa Y, Sai E & Mano H. “Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer” Cancer Sci 106, 1687-1692, 2015. [PubMed]
  2. Yamato A, Soda M, Ueno T, Kojima S, Sonehara K, Kawazu M, Sai E, Yamashita Y, Nagase T & Mano H. “Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-kappaB-activating potential” Cancer Sci 106, 1137-1142, 2015. [PubMed]
  3. Ikeda K, Horie-Inoue K, Ueno T, Suzuki T, Sato W, Shigekawa T, Osaki A, Saeki T, Berezikov E, Mano H & Inoue S. “miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A” Sci Rep 5, 13170, 2015. [PubMed]
  4. Mano H. “Second-generation ALK inhibitors” Clin Adv Hematol Oncol 13, 416-417, 2015. [PubMed]
  5. Suzuki HI, Katsura A, Yasuda T, Ueno T, Mano H, Sugimoto K & Miyazono K. “Small-RNA asymmetry is directly driven by mammalian Argonautes” Nat Struct Mol Biol 22, 512-521, 2015. [PubMed]
  6. Hashizume O, Ohnishi S, Mito T, Shimizu A, Iashikawa K, Nakada K, Soda M, Mano H, Togayachi S, Miyoshi H, Okita K & Hayashi J. “Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects” Sci Rep 5, 10434, 2015. [PubMed]
  7. Mano H. “The EML4-ALK oncogene: targeting an essential growth driver in human cancer” Proc Jpn Acad Ser B Phys Biol Sci 91, 193-201, 2015. [PubMed]

2014

  1. Yoshimi A, Toya T, Kawazu M, Ueno T, Tsukamoto A, Iizuka H, Nakagawa M, Nannya Y, Arai S, Harada H, Usuki K, Hayashi Y, Ito E, Kirito K, Nakajima H, Ichikawa M, Mano H & Kurokawa M. “Recurrent CDC25C mutations drive malignant transformation in FPD/AML” Nat Commun 5, 4770, 2014. [PubMed]
  2. Yasuda T, Ueno T, Fukumura K, Yamato A, Ando M, Yamaguchi H, Soda M, Kawazu M, Sai E, Yamashita Y, Murata M, Kiyoi H, Naoe T & Mano H. “Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation” Leukemia 28, 426-428, 2014. [PubMed]
  3. Nakamura Y, Taniguchi H, Mizoguchi K, Ikeda T, Motoshima K, Yamaguchi H, Nagashima S, Nakatomi K, Soda M, Mano H & Kohno S. “Secondary EML4-ALK-positive lung adenocarcinoma in a patient previously treated for acute lymphoblastic leukemia in childhood: a case report” Jpn J Clin Oncol 44:593-596, 2014. [PubMed]

2013

  1. Kawazu M, Ueno T, Kontani K, Ogita Y, Ando M, Fukumura K, Yamato A, Soda M, Takeuchi K, Miki Y, Yamaguchi H, Yasuda T, Naoe T, Yamashita Y, Katada T, Choi YL & Mano H. “Transforming mutations of RAC guanosine triphosphatases in human cancers” Proc Natl Acad Sci U S A 110:3029-3034, 2013. [PubMed]
  2. Ando M, Kawazu M, Ueno T, Fukumura K, Yamato A, Soda M, Yamashita Y, Choi YL, Yamasoba T & Mano H. “Cancer-associated missense mutations of caspase-8 activate nuclear factor-kappaB signaling” Cancer Sci 104:1002-1008, 2013. [PubMed]
  3. Fukumura K, Yamashita Y, Kawazu M, Sai E, Fujiwara SI, Nakamura N, Takeuchi K, Ando M, Miyazono K, Ueno T, Ozawa K & Mano H. “STK10 missense mutations associated with anti-apoptotic function” Oncol Rep 30:1542-1548, 2013. [PubMed]
  4. Ando K, Tsushima H, Matsuo E, Horio K, Tominaga-Sato S, Imanishi D, Imaizumi Y, Iwanaga M, Itonaga H, Yoshida S, Hata T, Moriuchi R, Kiyoi H, Nimer S, Mano H, Naoe T, Tomonaga M & Miyazaki Y. “Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation” J Biol Chem 288:9457-9467, 2013. [PubMed]
  5. Himpe E, Abdul Rahim SA, Verdood P, Mano H & Kooijman R. “Tec kinase stimulates cell survival in transfected Hek293T cells and is regulated by the anti-apoptotic growth factor IGF-I in human neutrophils” Cell Signal 25:666-673, 2013. [PubMed]
  6. Miyanaga A, Shimizu K, Noro R, Seike M, Kitamura K, Kosaihira S, Minegishi Y, Shukuya T, Yoshimura A, Kawamoto M, Tsuchiya S, Hagiwara K, Soda M, Takeuchi K, Yamamoto N, Mano H, Ishikawa Y & Gemma A. “Activity of EGFR-tyrosine kinase and ALK inhibitors for EML4-ALK-rearranged non-small-cell lung cancer harbored coexisting EGFR mutation” BMC Cancer 13:262, 2013. [PubMed]
  7. Nakamura M, Yasuda D, Hirota N, Yamamoto T, Yamaguchi S, Shimizu T & Nagamune T. “Amino acid residues of G-protein-coupled receptors critical for endoplasmic reticulum export and trafficking” Methods Enzymol 521:203-216, 2013. [PubMed]
  8. Ninomiya H, Kato M, Sanada M, Takeuchi K, Inamura K, Motoi N, Nagano H, Nomura K, Sakao Y, Okumura S, Mano H, Ogawa S & Ishikawa Y. “Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes” BMC Cancer 13:8, 2013. [PubMed]
  9. Suzuki HI, Matsuyama H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K & Miyazono K. “Computational dissection of distinct microRNA activity signatures associated with peripheral T cell lymphoma subtypes” Leukemia 27:2107-2111, 2013. [PubMed]
  10. Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S & Murakami M. “Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis” Nat Immunol 14:554-563, 2013. [PubMed]

2012

  1. Mano H. “ALKoma: a cancer subtype with a shared target” Cancer Discov 2:495-502, 2012. [PubMed]
  2. Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, Asaka R, Hamanaka W, Ninomiya H, Uehara H, Choi YL, Satoh Y, Okumura S, Nakagawa K, Mano H & Ishikawa Y. “RET, ROS1 and ALK fusions in lung cancer” Nat Med 18:378-381, 2012. [PubMed]
  3. Ng KP, Hillmer AM, Chuah CT, Juan WC, Ko TK, Teo AS, Ariyaratne PN, Takahashi N, Sawada K, Fei Y, Soh S, Lee WH, Huang JW, Allen JC, Jr., Woo XY, Nagarajan N, Kumar V, Thalamuthu A, Poh WT, Ang AL, Mya HT, How GF, Yang LY, Koh LP, Chowbay B, Chang CT, Nadarajan VS, Chng WJ, Than H, Lim LC, Goh YT, Zhang S, Poh D, Tan P, Seet JE, Ang MK, Chau NM, Ng QS, Tan DS, Soda M, Isobe K, Nothen MM, Wong TY, Shahab A, Ruan X, Cacheux-Rataboul V, Sung WK, Tan EH, Yatabe Y, Mano H, Soo RA, Chin TM, Lim WT, Ruan Y & Ong ST. “A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer” Nat Med 18:521-528, 2012. [PubMed]
  4. Soda M, Isobe K, Inoue A, Maemondo M, Oizumi S, Fujita Y, Gemma A, Yamashita Y, Ueno T, Takeuchi K, Choi YL, Miyazawa H, Tanaka T, Hagiwara K & Mano H. “A prospective PCR-based screening for the EML4-ALK oncogene in non-small cell lung cancer” Clin Cancer Res 18:5682-5689, 2012. [PubMed]
  5. Choi YL, Soda M, Ueno T, Hamada T, Haruta H, Yamato A, Fukumura K, Ando M, Kawazu M, Yamashita Y & Mano H. “Oncogenic MAP2K1 mutations in human epithelial tumors” Carcinogenesis 33:956-961, 2012. [PubMed]
  6. Sugawara E, Togashi Y, Kuroda N, Sakata S, Hatano S, Asaka R, Yuasa T, Yonese J, Kitagawa M, Mano H, Ishikawa Y & Takeuchi K. “Identification of anaplastic lymphoma kinase fusions in renal cancer: Large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method” Cancer 118:4427-4436, 2012. [PubMed]
  7. Togashi Y, Soda M, Sakata S, Sugawara E, Hatano S, Asaka R, Nakajima T, Mano H & Takeuchi K. “KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only” PLoS ONE 7:e31323, 2012. 22347464[PubMed]
  8. Ueno T, Yamashita Y, Soda M, Fukumura K, Ando M, Yamato A, Kawazu M, Choi YL & Mano H. “High-throughput resequencing of target-captured cDNA in cancer cells” Cancer Sci 103:131-135, 2012. [PubMed]
  9. Yamada T, Takeuchi S, Nakade J, Kita K, Nakagawa T, Nanjo S, Nakamura T, Matsumoto K, Soda M, Mano H, Uenaka T & Yano S. “Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells” Clin Cancer Res 18:3592-3602, 2012. [PubMed]
  10. Butler MO, Imataki O, Yamashita Y, Tanaka M, Ansen S, Berezovskaya A, Metzler G, Milstein MI, Mooney MM, Murray AP, Mano H, Nadler LM & Hirano N. “Ex vivo expansion of human CD8 T cells using autologous CD4 T cell help” PLoS ONE 7:e30229, 2012. [PubMed]
  11. Echigo R, Shimohata N, Karatsu K, Yano F, Kayasuga-Kariya Y, Fujisawa A, Ohto T, Kita Y, Nakamura M, Suzuki S, Mochizuki M, Shimizu T, Chung UI & Sasaki N. “Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage” J Transl Med 10:80, 2012. [PubMed]
  12. Kimura H, Nakajima T, Takeuchi K, Soda M, Mano H, Iizasa T, Matsui Y, Yoshino M, Shingyoji M, Itakura M, Itami M, Ikebe D, Yokoi S, Kageyama H, Ohira M & Nakagawara A. “ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity” Lung Cancer 75:66-72, 2012. [PubMed]

2011

  1. Takeuchi K, Soda M, Togashi Y, Ota Y, Sekiguchi Y, Hatano S, Asaka R, Noguchi M & Mano H. “Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma” Haematologica 96:464-467, 2011. [PubMed]
  2. Takeuchi K, Soda M, Togashi Y, Sugawara E, Hatano S, Asaka R, Okumura S, Nakagawa K, Mano H & Ishikawa Y. “Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification” Clin Cancer Res 17:3341-3348, 2011. [PubMed]
  3. Suzuki HI, Arase M, Matsuyama H, Choi YL, Ueno T, Mano H, Sugimoto K & Miyazono K. “MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation” Mol Cell 44:424-436, 2011. [PubMed]
  4. Iida A, Shinoe T, Baba Y, Mano H & Watanabe S. “Dicer plays essential roles for retinal development by regulation of survival and differentiation” Invest Ophthalmol Vis Sci 52:3008-3017, 2011. [PubMed]
  5. Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K & Miyazono K. “miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma” Blood 118:6881-6892, 2011. [PubMed]
  6. Nakamura M & Shimizu T. “Leukotriene receptors” Chem Rev 111:6231-6298, 2011. [PubMed]
  7. Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S & Yamada Y. “Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy” Haematologica 96:712-719, 2011. [PubMed]
  8. Tominaga-Sato S, Tsushima H, Ando K, Itonaga H, Imaizumi Y, Imanishi D, Iwanaga M, Taguchi J, Fukushima T, Yoshida S, Hata T, Moriuchi Y, Kuriyama K, Mano H, Tomonaga M & Miyazaki Y. “Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts” Int J Hematol 94:81-89, 2011. [PubMed]

2010

  1. Choi YL, Soda M, Yamashita Y, Ueno T, Takashima J, Nakajima T, Yatabe Y, Takeuchi K, Hamada T, Haruta H, Ishikawa Y, Kimura H, Mitsudomi T, Tanio Y & Mano H. “EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors” N Engl J Med 363:1734-1739, 2010. [PubMed]
  2. Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A & Mano H. “Array-based genomic resequencing of human leukemia” Oncogene 29:3723-3731, 2010. [PubMed]
  3. Hatanaka H, Takada S, Tsukui M, Choi YL, Kurashina K, Soda M, Yamashita Y, Haruta H, Hamada T, Tamada K, Hosoya Y, Sata N, Nagai H, Yasuda Y, Sugano K & Mano H. “Identification of the transforming activity of Indian hedgehog by retroviral expression screening” Cancer Sci 101:60-64, 2010. [PubMed]
  4. Hatanaka H, Tsukui M, Takada S, Kurashina K, Choi YL, Soda M, Yamashita Y, Haruta H, Hamada T, Ueno T, Tamada K, Hosoya Y, Sata N, Yasuda Y, Nagai H, Sugano K & Mano H. “Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening” Cancer Sci 101:54-59, 2010. [PubMed]
  5. Hashidate T, Murakami N, Nakagawa M, Ichikawa M, Kurokawa M, Shimizu T & Nakamura M. “AML1 enhances the expression of leukotriene B4 type-1 receptor in leukocytes” FASEB J 24:3500-3510, 2010. [PubMed]
  6. Hirota N, Yasuda D, Hashidate T, Yamamoto T, Yamaguchi S, Nagamune T, Nagase T, Shimizu T & Nakamura M. “Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor” J Biol Chem 285:5931-5940, 2010. [PubMed]
  7. Hori T, Sato Y, Takahashi N, Takio K, Yokomizo T, Nakamura M, Shimizu T & Miyano M. “Expression, purification and characterization of leukotriene B(4) receptor, BLT1 in Pichia pastoris” Protein Expr Purif 72:66-74, 2010. [PubMed]
  8. Iizuka Y, Okuno T, Saeki K, Uozaki H, Okada S, Misaka T, Sato T, Toh H, Fukayama M, Takeda N, Kita Y, Shimizu T, Nakamura M & Yokomizo T. “Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis” FASEB J 24:4678-4690, 2010. [PubMed]
  9. Mano H & Takeuchi K. “EML4-ALK fusion in lung” Am J Pathol 176:1552-1553, 2010. [PubMed]
  10. Nakajima T, Kimura H, Takeuchi K, Soda M, Mano H, Yasufuku K & Iizasa T. “Treatment of lung cancer with an ALK inhibitor after EML4-ALK fusion gene detection using endobronchial ultrasound-guided transbronchial needle aspiration” J Thorac Oncol 5:2041-2043, 2010. [PubMed]
  11. Nakamura M, Yasuda D, Hirota N & Shimizu T. “Specific ligands as pharmacological chaperones: The transport of misfolded G-protein coupled receptors to the cell surface” IUBMB Life 62:453-459, 2010. [PubMed]
  12. Osoegawa A, Nosaki K, Miyamoto H, Kometani T, Hirai F, Ondo K, Seto T, Sugio K, Choi YL, Soda M, Mano H & Ichinose Y. “Incidentally proven pulmonary "ALKoma"” Intern Med 49:603-606, 2010. [PubMed]
  13. Sakairi Y, Nakajima T, Yasufuku K, Ikebe D, Kageyama H, Soda M, Takeuchi K, Itami M, Iizasa T, Yoshino I, Mano H & Kimura H. “EML4-ALK fusion gene assessment using metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration” Clin Cancer Res 16:4938-4945, 2010. [PubMed]
  14. Susaki K, Kitanaka A, Dobashi H, Kubota Y, Kittaka K, Kameda T, Yamaoka G, Mano H, Mihara K & Ishida T. “Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte” Immunol Lett 127:135-142, 2010. [PubMed]
  15. Zhang MJ, Franklin S, Li Y, Wang S, Ru X, Mitchell-Jordan SA, Mano H, Stefani E, Ping P & Vondriska TM. “Stress signaling by Tec tyrosine kinase in the ischemic myocardium” Am J Physiol Heart Circ Physiol 299:H713-722, 2010. [PubMed]

2009

  1. Takeuchi K, Choi YL, Togashi Y, Soda M, Hatano S, Inamura K, Takada S, Ueno T, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y & Mano H. “KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer” Clin Cancer Res 15:3143-3149, 2009. [PubMed]
  2. Inamura K, Takeuchi K, Togashi Y, Hatano S, Ninomiya H, Motoi N, Mun MY, Sakao Y, Okumura S, Nakagawa K, Soda M, Choi YL, Mano H & Ishikawa Y. “EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset” Mod Pathol 22:508-515, 2009. [PubMed]
  3. Kaneda R, Takada S, Yamashita Y, Choi YL, Nonaka-Sarukawa M, Soda M, Misawa Y, Isomura T, Shimada K & Mano H. “Genome-wide histone methylation profile for heart failure” Genes Cells 14:69-77, 2009. [PubMed]
  4. Kano Y, Tanaka M, Akutsu M, Mori K, Yazawa Y, Mano H & Furukawa Y. “Schedule-dependent synergism and antagonism between pemetrexed and docetaxel in human lung cancer cell lines in vitro” Cancer Chemother Pharmacol 64:1129-1137, 2009. [PubMed]
  5. Murakami N, Hashidate T, Harayama T, Yokomizo T, Shimizu T & Nakamura M. “Transcriptional regulation of human G2A in monocytes/ macrophages: involvement of c/EBPs, Runx and Pu.1” Genes Cells 14:1441-1455, 2009. [PubMed]
  6. Takada S, Berezikov E, Choi YL, Yamashita Y & Mano H. “Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos” RNA 15:1507-1514, 2009. [PubMed]
  7. Tanaka M, Kano Y, Akutsu M, Tsunoda S, Izumi T, Yazawa Y, Miyawaki S, Mano H & Furukawa Y. “The cytotoxic effects of gemtuzumab ozogamicin (mylotarg) in combination with conventional antileukemic agents by isobologram analysis in vitro” Anticancer Res 29:4589-4596, 2009. [PubMed]
  8. Wada T, Yamashita Y, Saga Y, Takahashi K, Koinuma K, Choi YL, Kaneda R, Fujiwara S, Soda M, Watanabe H, Kurashina K, Hatanaka H, Enomoto M, Takada S, Mano H & Suzuki M. “Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries” Int J Oncol 35:973-976, 2009. [PubMed]
  9. Yasuda D, Okuno T, Yokomizo T, Hori T, Hirota N, Hashidate T, Miyano M, Shimizu T & Nakamura M. “Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum” FASEB J 23:1470-1481, 2009. [PubMed]

2008

  1. Soda M, Takada S, Takeuchi K, Choi YL, Enomoto M, Ueno T, Haruta H, Hamada T, Yamashita Y, Ishikawa Y, Sugiyama Y & Mano H. “A mouse model for EML4-ALK-positive lung cancer” Proc Natl Acad Sci U S A 105:19893-19897, 2008. [PubMed]
  2. Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, Wang L, Soda M, Kikuchi A, Igarashi T, Nakagawara A, Hayashi Y, Mano H & Ogawa S. “Oncogenic mutations of ALK kinase in neuroblastoma” Nature 455:971-974, 2008. [PubMed]
  3. Takada S, Yamashita Y, Berezikov E, Hatanaka H, Fujiwara SI, Kurashina K, Watanabe H, Enomoto M, Soda M, Choi YL & Mano H. “MicroRNA expression profiles of human leukemias” Leukemia 22:1274-1278, 2008. [PubMed]
  4. Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y & Mano H. “Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer” Cancer Res 68:4971-4976, 2008. [PubMed]
  5. Takeuchi K, Choi YL, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Takada S, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y & Mano H. “Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts” Clin Cancer Res 14:6618-6624, 2008. [PubMed]
  6. Fujiwara SI, Yamashita Y, Nakamura N, Choi YL, Ueno T, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Abe M, Ozawa K & Mano H. “High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays” Leukemia 22:1891-1898, 2008. [PubMed]
  7. Hase M, Yokomizo T, Shimizu T & Nakamura M. “Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins” J Biol Chem 283:12747-12755, 2008. [PubMed]
  8. Inamura K, Takeuchi K, Togashi Y, Nomura K, Ninomiya H, Okui M, Satoh Y, Okumura S, Nakagawa K, Soda M, Choi YL, Niki T, Mano H & Ishikawa Y. “EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers” J Thorac Oncol 3:13-17, 2008. [PubMed]
  9. Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T & Tomoike H. “High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project” Hum Mol Genet 17:617-627, 2008. [PubMed]
  10. Kurashina K, Yamashita Y, Ueno T, Koinuma K, Ohashi J, Horie H, Miyakura Y, Hamada T, Haruta H, Hatanaka H, Soda M, Choi YL, Takada S, Yasuda Y, Nagai H & Mano H. “Chromosome copy number analysis in screening for prognosis-related genomic regions in colorectal carcinoma” Cancer Sci 99:1835-1840, 2008. [PubMed]
  11. Mano H. “Non-solid oncogenes in solid tumors: EML4-ALK fusion genes in lung cancer” Cancer Sci 99:2349-2355, 2008. [PubMed]
  12. Mano H. “Epigenetic abnormalities in cardiac hypertrophy and heart failure” Environ Health Prev Med 13:25-29, 2008. [PubMed]
  13. Nagai K, Jinnai I, Hata T, Usui T, Sasaki D, Tsukasaki K, Sugahara K, Hishikawa Y, Yamada Y, Tanaka Y, Koji T, Mano H, Kamihira S & Tomonaga M. “Adhesion-dependent growth of primary adult T cell leukemia cells with down-regulation of HTLV-I p40Tax protein: a novel in vitro model of the growth of acute ATL cells” Int J Hematol 88:551-564, 2008. [PubMed]
  14. Onimaru Y, Tsukasaki K, Murata K, Imaizumi Y, Choi YL, Hasegawa H, Sugahara K, Yamada Y, Hayashi T, Nakashima M, Taguchi T, Mano H, Kamihira S & Tomonaga M. “Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met” Int J Oncol 33:697-703, 2008. [PubMed]
  15. Saga Y, Ohwada M, Suzuki M, Konno R, Kigawa J, Ueno S & Mano H. “Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma” Oncol Rep 20:1299-1303, 2008. [PubMed]
  16. Sato T, Toki T, Kanezaki R, Xu G, Terui K, Kanegane H, Miura M, Adachi S, Migita M, Morinaga S, Nakano T, Endo M, Kojima S, Kiyoi H, Mano H & Ito E. “Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome” Br J Haematol 141:681-688, 2008. [PubMed]

2007

  1. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y & Mano H. “Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer” Nature 448:561-566, 2007. [PubMed]
  2. Takada S & Mano H. “Profiling of microRNA expression by mRAP” Nature Protoc 2:3136-3145, 2007. [PubMed]
  3. Yamashita Y, Minoura K, Taya T, Fujiwara SI, Kurashina K, Watanabe H, Choi YL, Soda M, Hatanaka H, Enomoto M, Takada S & Mano H. “Analysis of chromosome copy number in leukemic cells by different microarray platforms” Leukemia 21:1333-1337, 2007. [PubMed]
  4. Choi YL, Kaneda R, Wada T, Fujiwara S, Soda M, Watanabe H, Kurashina K, Hatanaka H, Enomoto M, Takada S, Yamashita Y & Mano H. “Identification of a constitutively active mutant of JAK3 by retroviral expression screening” Leuk Res 31:203-209, 2007. [PubMed]
  5. Choi YL, Tsukasaki K, O’Neill MC, Yamada Y, Onimaru Y, Matsumoto K, Ohashi J, Yamashita Y, Tsutsumi S, Kaneda R, Takada S, Aburatani H, Kamihira S, Nakamura T, Tomonaga M & Mano H. “A genomic analysis of adult T-cell leukemia” Oncogene 26:1245-1255, 2007. [PubMed]
  6. Fujiwara S, Yamashita Y, Choi YL, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Ozawa K & Mano H. “Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening” Leuk Lymphoma 48:978-986, 2007. [PubMed]
  7. Furukawa Y, Vu HA, Akutsu M, Odgerel T, Izumi T, Tsunoda S, Matsuo Y, Kirito K, Sato Y, Mano H & Kano Y. “Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines” Leukemia 21:1005-1014, 2007. [PubMed]
  8. Hatanaka H, Takada S, Choi YL, Fujiwara S, Soda M, Enomoto M, Kurashina K, Watanabe H, Yamashita Y, Sugano K & Mano H. “Transforming activity of purinergic receptor P2Y, G-protein coupled, 2 revealed by retroviral expression screening” Biochem Biophys Res Commun 356:723-726, 2007. [PubMed]
  9. Kano Y, Akutsu M, Tsunoda S, Izumi T, Kobayashi H, Mano H & Furukawa Y. “Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines” Invest New Drugs 25:31-40, 2007. [PubMed]
  10. Mano H & Takada S. “mRAP, a sensitive method for determination of microRNA expression profiles” Methods 43:118-122, 2007. [PubMed]
  11. Oh I, Ozaki M, Miyazato A, Sato K, Meguro A, Muroi K, Nagai T, Mano H & Ozawa K. “Screening of genes responsible for differentiation of mouse mesenchymal stromal cells by DNA micro-array analysis of C3H10T1/2 and C3H10T1/2-derived cell lines” Cytotherapy 9:80-90, 2007. [PubMed]
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